Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena.

The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...

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Главные авторы:	Pamela Y Sandoval, Po-Hsuen Lee, Xiangzhou Meng, Geoffrey M Kapler
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2015-07-01
Серии:	PLoS Genetics
Online-ссылка:	http://europepmc.org/articles/PMC4517752?pdf=render
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