Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena.
The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential p...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2015-07-01
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| Colección: | PLoS Genetics |
| Acceso en línea: | http://europepmc.org/articles/PMC4517752?pdf=render |
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