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A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

Abstract Background Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new the...

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Autori principali: Menghan Wang, Tianxin Yu, Jinpeng Liu, Li Chen, Arnold J. Stromberg, John L. Villano, Susanne M. Arnold, Chunming Liu, Chi Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-12-01
Serie:BMC Bioinformatics
Soggetti:
Carcinogenesis
Somatic mutations
Pathway analysis
Functional annotations
Accesso online:https://doi.org/10.1186/s12859-019-3218-2
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