A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

Abstract Background Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new the...

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Autors principals:	Menghan Wang, Tianxin Yu, Jinpeng Liu, Li Chen, Arnold J. Stromberg, John L. Villano, Susanne M. Arnold, Chunming Liu, Chi Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-12-01
Col·lecció:	BMC Bioinformatics
Matèries:	Carcinogenesis Somatic mutations Pathway analysis Functional annotations
Accés en línia:	https://doi.org/10.1186/s12859-019-3218-2
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