A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

Abstract Background Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new the...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Menghan Wang, Tianxin Yu, Jinpeng Liu, Li Chen, Arnold J. Stromberg, John L. Villano, Susanne M. Arnold, Chunming Liu, Chi Wang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2019-12-01
Цуврал:	BMC Bioinformatics
Нөхцлүүд:	Carcinogenesis Somatic mutations Pathway analysis Functional annotations
Онлайн хандалт:	https://doi.org/10.1186/s12859-019-3218-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!