A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

Abstract Background Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new the...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Menghan Wang, Tianxin Yu, Jinpeng Liu, Li Chen, Arnold J. Stromberg, John L. Villano, Susanne M. Arnold, Chunming Liu, Chi Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-12-01
coleção:	BMC Bioinformatics
Assuntos:	Carcinogenesis Somatic mutations Pathway analysis Functional annotations
Acesso em linha:	https://doi.org/10.1186/s12859-019-3218-2
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!