Fluorescently labeled nuclear morphology is highly informative of neurotoxicity

Neurotoxicity can be detected in live microscopy by morphological changes such as retraction of neurites, fragmentation, blebbing of the neuronal soma and ultimately the disappearance of fluorescently labeled neurons. However, quantification of these features is often difficult, low-throughput, and...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shijie Wang, Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Steven Finkbeiner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-08-01
Schriftenreihe:	Frontiers in Toxicology
Schlagworte:	cell death microscopy light convolutional neural network genetically encoded biosensor live microscopy
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/ftox.2022.935438/full
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