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Fluorescently labeled nuclear morphology is highly informative of neurotoxicity

Neurotoxicity can be detected in live microscopy by morphological changes such as retraction of neurites, fragmentation, blebbing of the neuronal soma and ultimately the disappearance of fluorescently labeled neurons. However, quantification of these features is often difficult, low-throughput, and...

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Autori principali: Shijie Wang, Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Steven Finkbeiner
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-08-01
Serie:Frontiers in Toxicology
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Accesso online:https://www.frontiersin.org/articles/10.3389/ftox.2022.935438/full
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