Nobiletin enhances Doxorubicin sensitivity in osteosarcoma through ER stress-induced apoptosis mediated by the PI3K/AKT pathway

Abstract Osteosarcoma (OS) is the most prevalent primary malignant bone tumor, and chemotherapy resistance represents one of the primary challenges in its treatment. Nobiletin (Nob), a natural compound with anti-tumor properties, has an unclear mechanism of action but may increase the sensitivity of...

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Hlavní autoři:	Fei Liu, Daotong Yuan, Zhimeng Zhang, Rui Gong, Ximin Jin, Chaolu Wang, Wenpeng Xie, Yongkui Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-03-01
Edice:	Scientific Reports
Témata:	Osteosarcoma Nobiletin Doxorubicin Chemoresistance Apoptosis Endoplasmic reticulum stress
On-line přístup:	https://doi.org/10.1038/s41598-026-44757-1
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