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Abietic acid protects cardiomyocytes from doxorubicin-induced apoptosis by modulating PI3K/Akt-mediated mitochondrial apoptosis

Doxorubicin (DOX) is a potent chemotherapeutic agent, but its clinical utility is severely compromised by dose-dependent, irreversible cardiotoxicity. There is an urgent need to develop novel drugs or therapeutic strategies to reduce DOX-induced cardiotoxicity. Abietic acid (AA), a natural product,...

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Main Authors: Jun Sang, Yang Tang
Format: Artigo
Language:Inglês
Published: Elsevier 2026-06-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
Doxorubicin
Cardiotoxicity
PI3K/Akt
Apoptosis
Network pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142526000643
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