Nobiletin enhances Doxorubicin sensitivity in osteosarcoma through ER stress-induced apoptosis mediated by the PI3K/AKT pathway

Abstract Osteosarcoma (OS) is the most prevalent primary malignant bone tumor, and chemotherapy resistance represents one of the primary challenges in its treatment. Nobiletin (Nob), a natural compound with anti-tumor properties, has an unclear mechanism of action but may increase the sensitivity of...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Fei Liu, Daotong Yuan, Zhimeng Zhang, Rui Gong, Ximin Jin, Chaolu Wang, Wenpeng Xie, Yongkui Zhang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2026-03-01
Σειρά:	Scientific Reports
Θέματα:	Osteosarcoma Nobiletin Doxorubicin Chemoresistance Apoptosis Endoplasmic reticulum stress
Διαθέσιμο Online:	https://doi.org/10.1038/s41598-026-44757-1
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!