Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks an actionable target with limited treatment options beyond conventional chemotherapy. Therapeutic failure is often encountered due to inherent or acquired resistance to chemotherapy. Previous studies i...

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Autores principales:	Andrew N. Hakeem, Dina M. El-Kersh, Olfat Hammam, Aliaa Elhosseiny, Amr Zaki, Kohinour Kamel, Lidia Yasser, Marina Barsom, Menatallah Ahmed, Mohamed Gamal, Yasmeen M. Attia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2024-08-01
Colección:	Scientific Reports
Materias:	Triple-negative breast cancer Piperine Doxorubicin Cancer stem cells PI3K/Akt/mTOR PTEN
Acceso en línea:	https://doi.org/10.1038/s41598-024-65508-0
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