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The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release of inflammatory cytokines such as IL-6 and IL-1β...

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Main Authors: Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone
Format: Artigo
Language:Inglês
Published: Elsevier 2022-05-01
Series:Virus Research
Subjects:
HHV-6A
Neuroinflammation
ER stress
4-PBA
DMF
Astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170222000545
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