The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release of inflammatory cytokines such as IL-6 and IL-1β...

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Hlavní autoři:	Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2022-05-01
Edice:	Virus Research
Témata:	HHV-6A Neuroinflammation ER stress 4-PBA DMF Astrocytes
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0168170222000545
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