The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release of inflammatory cytokines such as IL-6 and IL-1β...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2022-05-01
سلاسل:	Virus Research
الموضوعات:	HHV-6A Neuroinflammation ER stress 4-PBA DMF Astrocytes
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S0168170222000545
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!