The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release of inflammatory cytokines such as IL-6 and IL-1β...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2022-05-01
Σειρά:	Virus Research
Θέματα:	HHV-6A Neuroinflammation ER stress 4-PBA DMF Astrocytes
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S0168170222000545
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