Drug Responsiveness in Patient-Derived Rectal Organoids Correlates with Clinical Response in CF Subjects: A Real-Life Analysis

Pharmacological modulators of CFTR have significantly changed the cystic fibrosis (CF) phenotype of subjects affected by this multi-organ disease. Here, we evaluated the CFTR function analysis (short-circuit chamber in colonoids) in response to Elexacaftor/Tezacaftor/Ivacaftor (ETI) with the clinica...

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Principais autores:	Karina Kleinfelder, Paola Lecca, Roberta Valeria Latorre, Chiara Mortali, Sara Casati, Sofia Vanerio, Claudio Sorio, Paola Melotti
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2026-02-01
叢編:	Scientia Pharmaceutica
主題:	2D monolayer-rectal organoids personalized medicine Ussing CFTR modulators cystic fibrosis primary cell models
在線閱讀:	https://www.mdpi.com/2218-0532/94/1/13
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