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Drug Responsiveness in Patient-Derived Rectal Organoids Correlates with Clinical Response in CF Subjects: A Real-Life Analysis

Pharmacological modulators of CFTR have significantly changed the cystic fibrosis (CF) phenotype of subjects affected by this multi-organ disease. Here, we evaluated the CFTR function analysis (short-circuit chamber in colonoids) in response to Elexacaftor/Tezacaftor/Ivacaftor (ETI) with the clinica...

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Wedi'i Gadw mewn:
Prif Awduron: Karina Kleinfelder, Paola Lecca, Roberta Valeria Latorre, Chiara Mortali, Sara Casati, Sofia Vanerio, Claudio Sorio, Paola Melotti
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2026-02-01
Cyfres:Scientia Pharmaceutica
Pynciau:
2D monolayer-rectal organoids
personalized medicine
Ussing
CFTR modulators
cystic fibrosis
primary cell models
Mynediad Ar-lein:https://www.mdpi.com/2218-0532/94/1/13
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