Drug Responsiveness in Patient-Derived Rectal Organoids Correlates with Clinical Response in CF Subjects: A Real-Life Analysis

Pharmacological modulators of CFTR have significantly changed the cystic fibrosis (CF) phenotype of subjects affected by this multi-organ disease. Here, we evaluated the CFTR function analysis (short-circuit chamber in colonoids) in response to Elexacaftor/Tezacaftor/Ivacaftor (ETI) with the clinica...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Karina Kleinfelder, Paola Lecca, Roberta Valeria Latorre, Chiara Mortali, Sara Casati, Sofia Vanerio, Claudio Sorio, Paola Melotti
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-02-01
Serie:	Scientia Pharmaceutica
Soggetti:	2D monolayer-rectal organoids personalized medicine Ussing CFTR modulators cystic fibrosis primary cell models
Accesso online:	https://www.mdpi.com/2218-0532/94/1/13
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!