New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (<b>7</b>) or aminoalkyl (<b>8</b>) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. All compounds...

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Autors principals:	Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-12-01
Col·lecció:	Molecules
Matèries:	4-amino-2,3-polymethylenequinolines butylated hydroxytoluene (BHT) acetylcholinesterase (AChE) butyrylcholinesterase (BChE) antioxidants neuroprotection
Accés en línia:	https://www.mdpi.com/1420-3049/25/24/5891
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