Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: <i>N</i>-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-<i>N</i>-acyl-alkylene (<b>3</b>) and bis-<i>N</i>-thiourea-alkylene (<b>5</b>) —as potential m...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2022-02-01
Sarja:	Molecules
Aiheet:	amiridine <i>N</i>-acylamide thiourea acetylcholinesterase (AChE) butyrylcholinesterase (BChE) antioxidants
Linkit:	https://www.mdpi.com/1420-3049/27/3/1060
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