Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: <i>N</i>-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-<i>N</i>-acyl-alkylene (<b>3</b>) and bis-<i>N</i>-thiourea-alkylene (<b>5</b>) —as potential m...

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Hlavní autoři:	Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-02-01
Edice:	Molecules
Témata:	amiridine <i>N</i>-acylamide thiourea acetylcholinesterase (AChE) butyrylcholinesterase (BChE) antioxidants
On-line přístup:	https://www.mdpi.com/1420-3049/27/3/1060
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