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Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated in vivo. For this, we applied three mouse models of KRAS-mutant LADC to two different MC-deficient mouse strains (cKitWsh and Cpa3.Cre). Moreover, we derived MC gene...

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Hoofdauteurs: Ioannis Lilis, Giannoula Ntaliarda, Vassilios Papaleonidopoulos, Georgia A Giotopoulou, Maria Oplopoiou, Antonia Marazioti, Magda Spella, Sebastian Marwitz, Torsten Goldmann, Vasiliki Bravou, Ioanna Giopanou, Georgios T. Stathopoulos
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis Group 2019-07-01
Reeks:OncoImmunology
Onderwerpen:
carboxypeptidase 3/mutation/il
1β/lung cancer/urethane
Online toegang:http://dx.doi.org/10.1080/2162402X.2019.1593802
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