Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated in vivo. For this, we applied three mouse models of KRAS-mutant LADC to two different MC-deficient mouse strains (cKitWsh and Cpa3.Cre). Moreover, we derived MC gene...

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Autors principals:	Ioannis Lilis, Giannoula Ntaliarda, Vassilios Papaleonidopoulos, Georgia A Giotopoulou, Maria Oplopoiou, Antonia Marazioti, Magda Spella, Sebastian Marwitz, Torsten Goldmann, Vasiliki Bravou, Ioanna Giopanou, Georgios T. Stathopoulos
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2019-07-01
Col·lecció:	OncoImmunology
Matèries:	carboxypeptidase 3/mutation/il 1β/lung cancer/urethane
Accés en línia:	http://dx.doi.org/10.1080/2162402X.2019.1593802
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