NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Actively proliferating cancer cells require sufficient amount of NADH and NADPH for biogenesis and to protect cells from the detrimental effect of reactive oxygen species. As both normal and cancer cells share the same NAD biosynthetic and metabolic pathways, selectively lowering levels of NAD(H) an...

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Hlavní autoři:	Alvinsyah Adhityo Pramono, Gulam M. Rather, Herry Herman, Keri Lestari, Joseph R. Bertino
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-02-01
Edice:	Biomolecules
Témata:	nampt inhibitor nadk inhibitor dihydrofolate reductase idh mutation nad/nadph pool
On-line přístup:	https://www.mdpi.com/2218-273X/10/3/358
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!