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NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity

Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+ to generate NADP+, which plays a crucial role in maintaining NAD+/NADP+ homeostasis, cellular redox balance, and metabolism. However, how human NADK activity is regulated, and how dysregulation or mutation of NADK is linked t...

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Principais autores: Mengxue Hu, Fuxing Wang, Yue Zhu, Yi Yao, Huadong Pei, Zheng Liu, Pingfeng Zhang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2025-07-01
Serier:Genes and Diseases
Fag:
Chemotherapy resistance
Lung cancer
Methylation
NADK mutants
NADK tetramer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352304224003076
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