NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

Summary: Metabolic adaptations and the signaling events that control them promote the survival of pancreatic ductal adenocarcinoma (PDAC) at the fibrotic tumor site, overcoming stresses associated with nutrient and oxygen deprivation. Recently, rewiring of NADPH production has been shown to play a k...

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Autors principals:	Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, Bethany E. Schaffer, John M. Asara, Elena Piskounova, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-06-01
Col·lecció:	Cell Reports
Matèries:	NADK PDAC NADP+ NADPH KRAS PKC
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124721005970
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