Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations show...

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Autors principals:	Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2016-12-01
Col·lecció:	Molecules
Matèries:	microtubule microtubule stabilizer microtubule destabilizer cancer colchicine site
Accés en línia:	http://www.mdpi.com/1420-3049/21/12/1661
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