Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations show...

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Autori principali:	Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2016-12-01
Serie:	Molecules
Soggetti:	microtubule microtubule stabilizer microtubule destabilizer cancer colchicine site
Accesso online:	http://www.mdpi.com/1420-3049/21/12/1661
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