Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations show...

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Principais autores:	Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2016-12-01
coleção:	Molecules
Assuntos:	microtubule microtubule stabilizer microtubule destabilizer cancer colchicine site
Acesso em linha:	http://www.mdpi.com/1420-3049/21/12/1661
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