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Edaravone Dexborneol Treatment Attenuates Neuronal Apoptosis and Improves Neurological Function by Suppressing 4-HNE-Associated Oxidative Stress After Subarachnoid Hemorrhage

Edaravone dexborneol is a novel neuroprotective drug that comprises edaravone and (+)-borneol in a 4:1 ratio. Phase II and III studies have demonstrated that Chinese patients treated with edaravone dexborneol within 48 h of AIS onset have better functional outcomes than those treated with edaravone...

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Principais autores: Qian Chen, Yichen Cai, Xiaoyu Zhu, Jing Wang, Feng Gao, Mingfeng Yang, Leilei Mao, Zongyong Zhang, Baoliang Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
coleção:Frontiers in Pharmacology
Assuntos:
oxidative stress
subarachnoid hemorrhage
edaravone dexborneol
4-HNE
edaravone
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.848529/full
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