IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases, however, the impact of inflammation on Tregs remains controversial. We challenged human Tregs ex-vivo with pro-inflammatory cytokines IL-6 and TNFα and observed greatly enhanced proliferation stimulated by...

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Үндсэн зохиолчид:	Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2021-12-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	Tregs inflammation IL-6 TNFα CD28 signaling metabolomics
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.783282/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!