IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases, however, the impact of inflammation on Tregs remains controversial. We challenged human Tregs ex-vivo with pro-inflammatory cytokines IL-6 and TNFα and observed greatly enhanced proliferation stimulated by...

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Egile Nagusiak:	Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2021-12-01
Saila:	Frontiers in Immunology
Gaiak:	Tregs inflammation IL-6 TNFα CD28 signaling metabolomics
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.783282/full
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