IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases, however, the impact of inflammation on Tregs remains controversial. We challenged human Tregs ex-vivo with pro-inflammatory cytokines IL-6 and TNFα and observed greatly enhanced proliferation stimulated by...

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Hlavní autoři:	Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-12-01
Edice:	Frontiers in Immunology
Témata:	Tregs inflammation IL-6 TNFα CD28 signaling metabolomics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.783282/full
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