Mild activation of the mitochondrial unfolded protein response increases lifespan without increasing resistance to stress

The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway that responds to mitochondrial insults by altering gene expression to recover mitochondrial homeostasis. The mitoUPR is mediated by the stress-activated transcription factor ATFS-1 (activating transcription factor ass...

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Autors principals:	Alexa Di Pede, Bokang Ko, Abdelrahman AlOkda, Aura A. Tamez González, Shusen Zhu, Jeremy M. Van Raamsdonk
Format:	Artigo
Idioma:	Inglês
Publicat:	The Royal Society 2025-04-01
Col·lecció:	Open Biology
Matèries:	ageing stress resistance mitochondrial unfolded protein response Caenorhabditis elegans genetics ATFS-1
Accés en línia:	https://royalsocietypublishing.org/doi/10.1098/rsob.240358
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