Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants

Mutations that result in a mild impairment of mitochondrial function can extend longevity. Previous studies have shown that the increase in lifespan is dependent on stress responsive transcription factors, including DAF-16/FOXO, which exhibits increased nuclear localization in long-lived mitochondri...

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Hlavní autoři:	Annika Traa, Hazel Shields, Abdelrahman AlOkda, Zenith D. Rudich, Bokang Ko, Jeremy M. Van Raamsdonk
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-05-01
Edice:	Frontiers in Aging
Témata:	aging lifespan stress resistance endosomal trafficking C. elegans genetics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fragi.2023.1145198/full
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