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Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants

Mutations that result in a mild impairment of mitochondrial function can extend longevity. Previous studies have shown that the increase in lifespan is dependent on stress responsive transcription factors, including DAF-16/FOXO, which exhibits increased nuclear localization in long-lived mitochondri...

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Principais autores: Annika Traa, Hazel Shields, Abdelrahman AlOkda, Zenith D. Rudich, Bokang Ko, Jeremy M. Van Raamsdonk
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-05-01
Serier:Frontiers in Aging
Fag:
aging
lifespan
stress resistance
endosomal trafficking
C. elegans
genetics
Online adgang:https://www.frontiersin.org/articles/10.3389/fragi.2023.1145198/full
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