Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants

Mutations that result in a mild impairment of mitochondrial function can extend longevity. Previous studies have shown that the increase in lifespan is dependent on stress responsive transcription factors, including DAF-16/FOXO, which exhibits increased nuclear localization in long-lived mitochondri...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Annika Traa, Hazel Shields, Abdelrahman AlOkda, Zenith D. Rudich, Bokang Ko, Jeremy M. Van Raamsdonk
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2023-05-01
Serija:	Frontiers in Aging
Teme:	aging lifespan stress resistance endosomal trafficking C. elegans genetics
Online dostop:	https://www.frontiersin.org/articles/10.3389/fragi.2023.1145198/full
Oznake:	Označite Brez oznak, prvi označite!