Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences

Abstract Background Proline racemase (PRAC) enzymes of Trypanosoma cruzi (TcPRAC), the agent of Chagas disease, and Trypanosoma vivax (TvPRAC), the agent of livestock trypanosomosis, have been implicated in the B-cells polyclonal activation contributing to immunosuppression and the evasion of host d...

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Váldodahkkit:	Zuleima C Caballero, Andre G Costa-Martins, Robson C Ferreira, João M P Alves, Myrna G Serrano, Erney P Camargo, Gregory A Buck, Paola Minoprio, Marta M G Teixeira
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2015-04-01
Ráidu:	Parasites & Vectors
Fáttát:	Proline racemase Trypanosoma cruzi Trypanosoma vivax Trypanosoma rangeli Horizontal gene transfer Gene loss
Liŋkkat:	https://doi.org/10.1186/s13071-015-0829-y
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