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Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection

IL-10, an anti-inflammatory cytokine, plays a crucial role in limiting immune responses to pathogens, preventing host damage. However, the mechanisms underlying Brucella-mediated IL-10 production remain incompletely understood. In this study, we demonstrate that the proline racemase protein A (PrpA)...

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Sábháilte in:
Príomhchruthaitheoirí: Huan Zhang, Xueyu Tao, Yuanzhi Wang, Yueli Wang, Huilin Hou, Xiaoyu Deng, Zhenyu Xu, Xujin Xia, Mingguo Xu, Zhen Wang, Changsuo Zhang, Zhumanov Kairat Toksanbaevich, Jinliang Sheng, Zhongchen Ma, Jihai Yi, Chuangfu Chen
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2026-06-01
Sraith:Frontiers in Immunology
Ábhair:
Brucella melitensis M5-90
IL-10
proline racemase
tumor progression locus 2
vaccine
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1808256/full
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