Cardiac troponin and tropomyosin bind to F‐actin cooperatively, as revealed by fluorescence microscopy

In cardiac muscle, binding of troponin (Tn) and tropomyosin (Tpm) to filamentous (F)‐actin forms thin filaments capable of Ca2+‐dependent regulation of contraction. Tpm binds to F‐actin in a head‐to‐tail fashion, while Tn stabilizes these linkages. Valuable structural and functional information has...

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Detalhes bibliográficos

Principais autores:	Christopher Solís, John M. Robinson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2020-07-01
Colecção:	FEBS Open Bio
Assuntos:	binding isotherm Monte Carlo protein–protein interactions quantitative imaging stochastic simulation
Acesso em linha:	https://doi.org/10.1002/2211-5463.12876
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