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Cardiac troponin and tropomyosin bind to F‐actin cooperatively, as revealed by fluorescence microscopy

In cardiac muscle, binding of troponin (Tn) and tropomyosin (Tpm) to filamentous (F)‐actin forms thin filaments capable of Ca2+‐dependent regulation of contraction. Tpm binds to F‐actin in a head‐to‐tail fashion, while Tn stabilizes these linkages. Valuable structural and functional information has...

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Bibliografiske detaljer
Principais autores: Christopher Solís, John M. Robinson
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2020-07-01
Serier:FEBS Open Bio
Fag:
Online adgang:https://doi.org/10.1002/2211-5463.12876
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