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Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

Abstract Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis...

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I tiakina i:
Ngā kaituhi matua: Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Oxford University Press 2021-06-01
Rangatū:ESC Heart Failure
Ngā marau:
Blood cell mutations
Clonal haematopoiesis
Heart failure
Age
Urunga tuihono:https://doi.org/10.1002/ehf2.13297
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