Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

Abstract Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis...

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主要な著者:	Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 2021-06-01
シリーズ:	ESC Heart Failure
主題:	Blood cell mutations Clonal haematopoiesis Heart failure Age
オンライン･アクセス:	https://doi.org/10.1002/ehf2.13297
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