Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution

Abstract Background Genomic alterations are a hallmark of cancer, and extrachromosomal DNA (ecDNA) has emerged as a key source of oncogene selection, tumor growth, and drug resistance. The intratumor heterogeneity and clonal selection of ecDNA is, however, poorly understood. Results In this study, w...

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Autors principals:	Josephine Deleuran Hendriksen, Alessio Locallo, Balthasar Clemens Schlotmann, Francisco Germán Rodríguez González, Jane Skjøth-Rasmussen, Christina Westmose Yde, Dorte Schou Nørøxe, Hans Skovgaard Poulsen, Ulrik Lassen, Joachim Weischenfeldt
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-01-01
Col·lecció:	Genome Biology
Matèries:	Extrachromosomal DNA Cancer Single cell Clonal evolution Long-read sequencing Oncogene amplification
Accés en línia:	https://doi.org/10.1186/s13059-026-03933-2
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