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Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution

Abstract Background Genomic alterations are a hallmark of cancer, and extrachromosomal DNA (ecDNA) has emerged as a key source of oncogene selection, tumor growth, and drug resistance. The intratumor heterogeneity and clonal selection of ecDNA is, however, poorly understood. Results In this study, w...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Josephine Deleuran Hendriksen, Alessio Locallo, Balthasar Clemens Schlotmann, Francisco Germán Rodríguez González, Jane Skjøth-Rasmussen, Christina Westmose Yde, Dorte Schou Nørøxe, Hans Skovgaard Poulsen, Ulrik Lassen, Joachim Weischenfeldt
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-01-01
Schriftenreihe:Genome Biology
Schlagworte:
Extrachromosomal DNA
Cancer
Single cell
Clonal evolution
Long-read sequencing
Oncogene amplification
Online-Zugang:https://doi.org/10.1186/s13059-026-03933-2
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