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Machine learning identified extrachromosomal DNA-related 12 gene signatures to predict cancer immunotherapy response

Abstract Extrachromosomal circular DNA (ecDNA) has emerged as a critical determinant of poor clinical outcomes and immune escape in tumors, but the high cost and technical complexity of current detecting techniques limit its broader investigation in cancer immunotherapy. Leveraging the combined mach...

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Principais autores: Yan Ju, Jingwei Zhang, Jiaming Deng, Xingyuan Wu, Haotian Yang, Changyu Tao, Xiao Li
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-12-01
Series:Cancer Cell International
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Acceso en liña:https://doi.org/10.1186/s12935-025-04056-7
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