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Analysis of essential genes in Clostridioides difficile by CRISPRi and Tn-seq

ABSTRACT Essential genes are interesting in their own right and as potential antibiotic targets. To date, only one report has identified essential genes on a genome-wide scale in Clostridioides difficile, a problematic pathogen for which treatment options are limited. That foundational study used la...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Maia E. Alberts, Micaila P. Kurtz, Ute Müh, Jonathon P. Bernardi, Kevin W. Bollinger, Horia A. Dobrila, Leonard Duncan, Hannah M. Laster, Andres J. Orea, Anthony G. Pannullo, Juan G. Rivera-Rosado, Facundo V. Torres, Craig D. Ellermeier, David S. Weiss
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2025-10-01
Schriftenreihe:Journal of Bacteriology
Schlagworte:
CRISPRi
Tn-seq
Online-Zugang:https://journals.asm.org/doi/10.1128/jb.00220-25
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