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Analysis of essential genes in Clostridioides difficile by CRISPRi and Tn-seq

ABSTRACT Essential genes are interesting in their own right and as potential antibiotic targets. To date, only one report has identified essential genes on a genome-wide scale in Clostridioides difficile, a problematic pathogen for which treatment options are limited. That foundational study used la...

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Главные авторы: Maia E. Alberts, Micaila P. Kurtz, Ute Müh, Jonathon P. Bernardi, Kevin W. Bollinger, Horia A. Dobrila, Leonard Duncan, Hannah M. Laster, Andres J. Orea, Anthony G. Pannullo, Juan G. Rivera-Rosado, Facundo V. Torres, Craig D. Ellermeier, David S. Weiss
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2025-10-01
Серии:Journal of Bacteriology
Предметы:
CRISPRi
Tn-seq
Online-ссылка:https://journals.asm.org/doi/10.1128/jb.00220-25
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