Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates

Abstract Background An excess of nonsynonymous substitutions, over neutrality, is considered evidence of positive Darwinian selection. Inference for proteins often relies on estimation of the nonsynonymous to synonymous ratio (ω = d N/d S) within a codon model. However, to ease computational difficu...

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Ngā kaituhi matua:	Katherine A. Dunn, Toby Kenney, Hong Gu, Joseph P. Bielawski
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2019-01-01
Rangatū:	BMC Evolutionary Biology
Ngā marau:	Codon model Positive selection Protein evolution Multiple nucleotide mutations Multiple nonsynonymous rates M-series models
Urunga tuihono:	http://link.springer.com/article/10.1186/s12862-018-1326-7
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates

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